Y. Zhang#, G. Liao#, M. Wang#, Z. Zhang#, L. Liu, Y. Song, D. Wang, T. Hao, J. Feng, B. Xia, Y. Wang, X. Tang*, Y. Chen*. Human-associated bacteria adopt an unusual route for synthesizing 3-acetylated tetramates for environmental adaptation. Microbiome Accepted

B. R. Terlouw, … X. Tang … T. Weber*, M. H. Medema*. MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters. Nucleic Acids Research 2023, 51(D1): D603-D610

G. Liao, C. Mi, L. Yang, H. Zhang, X. Ding, M. Cai, H. Wang, W. Mei*, H. Dai*, X. Tang*. Para-quinone methide-mediated nonenzymatic formation of chalcane-containing dimers in dragon’s blood. Organic Letters 2022, 24(50): 9275–9280

M. Cai and X. Tang*. Human archaea and associated metabolites in health and disease. Biochemistry 2022, 61(24): 2835–2840

H. Zhang, G. Liao, X. Luo*, X. Tang*. Harnessing nature’s biosynthetic capacity to facilitate total synthesis. National Science Review 2022, 9(10): nwac178

H. Zhang, X. Tang*. Combining microbial and chemical syntheses for the production of complex natural products. Chinese Journal of Natural Medicines 2022, 20(10): 1-8

L. Hou, H. Tian, L. Wang, Z. E. Ferris, J. Wang, M. Cai, E. A. Older, M. R. K. Raja, D. Xue, W. Sun, P. Nagarkatti, M. Nagarkatti, H. Chen, D. Fan, X. Tang*, J. Li*. Identification and biosynthesis of pro-inflammatory sulfonolipids from an opportunistic pathogen Chryseobacterium gleum. ACS Chemical Biology 2022, 17(5): 1197–1206

J. Baker, X. Tang, S. LaBonte, C. Uranga, A. Edlund. mucG, mucH, and mucI modulate production of mutanocyclin and reutericyclins in Streptococcus mutans B04Sm5. Journal of Bacteriology 2022, 204(5): e0004222

D. Xue, E. A. Older, Z. Zhong, Z. Shang, N. Chen, N. Dittenhauser, L. Hou, M. D. Walla, S. Dong, X. Tang, P. Nagarkatti, M. Nagarkatti, Y. Li*, J. Li*. Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes. Nature Communications 2022, 13: 1647

X. Yin, G. Zhou, M. Cai, Q. Zhu, T. Richter-Heitmann, D. A. Aromokeye, Y. Liu, R. Nimzyk, Q. Zheng, X. Tang, M. Elvert, M. Li, M. W. Friedrich. Catabolic protein degradation in marine sediments confined to distinct archaea. The ISME Journal 2022, 16: 1617–1626

M. Cai, S. Kandalai, X. Tang*, Q. Zheng*. Contributions of human-associated archaeal metabolites to tumor microenvironment and carcinogenesis. Microbiology Spectrum 2022, 10(2): e02367-21

M. Cai, X. Yin, X. Tang, C. Zhang, Q. Zheng*, M. Li*. Metatranscriptomics reveals different features of methanogenic archaea among global vegetated coastal ecosystems. Science of the Total Environment 2022, 802: 149848

G. Liao, X. Tang*. Mining the microbial chemistry behind tooth decay. Biochemistry 2022, 61(24): 2779–2781

L. Hou, Y. Li, Q. Wu, M. Li, X. Tang, P. Nagarkatti, M. Nagarkatti, Y. Liu, L. Li, D. Fan, T. S. Bugni, Z. Shang*, J. Li*. Discovery of anti-infective adipostatins through bioactivity-guided isolation and heterologous expression of a type Ⅲ polyketide synthase. Bioorganic Chemistry 2021, 112: 104925

Z. Shang, Z. Ferris, D. Sweeney, A. Chase, C. Yuan, Y. Hui, L. Hou, E. Older, D. Xue, X. Tang, W. Zhang, P. Nagarkatti, M. Nagarkatti, T. Testerman, P. R. Jensen, J. Li#. Grincamycins P−T: rearranged angucycline glycosides from marine sediment-derived Streptomyces sp. CNZ-748 inhibit the rare cancer pseudomyxoma peritonei in vitro. Journal of Natural Products 2021, 84(5): 1638–1648

S. Xing, Y. Hu, Z. Yin, M. Liu, X. Tang, M. Fang, T. Huan*. Retrieving and utilizing hypothetical neutral losses from tandem mass spectra for spectral similarity analysis and unknown metabolite annotation. Analytical Chemistry 2020, 92(21): 14476–14483

X. Tang, Y. Kudo, J. Baker, S. LaBonte, P. A. Jordan, S. M. K. Mckinnie, J. Guo, T. Huan, B. S. Moore*, A. Edlund*. Cariogenic Streptococcus mutans produces strain-specific antibiotics that impair commensal colonization. ACS Infectious Diseases, 6(4), 563-571 (2020)

J. J. Zhang, X. Tang, T. Huan, A. C. Ross, B. S. Moore*. Pass-back chain extension expands multi-modular assembly line biosynthesis. Nature Chemical Biology 2020, 16: 42–49

J. J. Zhang*, X. Tang, B. S. Moore*. Genetic platforms for heterologous expression of microbial natural products. Natural Product Reports 2019, 36: 1313-1332

G. Aleti, J. L. Baker, X. Tang, R. Alvarez, M. Boltelho, N. C. Tran, A. V. Melnik, C. Zhong, M. Ernst, P.C. Dorrestein, A. Edlund*. Identification of the bacterial biosynthetic gene clusters of the oral microbiome illuminates the unexplored social language of bacteria during health and disease. mBio 2019, 10(2): e00321-19

J. L. Baker, E. L. Hendrickson, X. Tang, R. Lux, X. He, A. Edlund, J. S. McLean, W. Shi*. Klebsiella and Providencia emerge as lone survivors following long-term starvation of oral microbiota, PNAS 2019, 116(17): 8499-8504

J. J. Zhang, K. Yamanaka, X. Tang*, B. S. Moore*. Direct cloning and heterologous expression of natural product biosynthetic gene clusters by transformation-associated recombination. Methods in Enzymology 2019, 621: 87-110